Continue reading “Puberty Blockers”
If informed consent is one of the pillars of clinical bioethics, puberty blockers fail the test, according to a leading psychiatrist and constitutional lawyer writing in the magazine Commentary. Paul McHugh, an emeritus professor of psychiatry at Johns Hopkins, and Gerard V. Bradley, a law professor at Notre Dame, argue that neither young people nor their parents can possibly understand what they are missing by delaying puberty, one of the most mysterious aspects of human physiology.MercatorNet.com
Friday, I got a PICC line installed. I was told the procedure would take 45 minutes, and technically, it did.
This did not, however, count the set-up and the follow-up. It took about an hour to assemble the mise en place, and then after the line was in, it took another hour for a chest x-ray and to generate the appointments for the weekly dressing change.
However, the line seems to be accomplishing its purpose. Right after the line was installed, it was used to draw blood for my lab tests, and today it was used for the infusion of my monoclonal antibodies. I decided to accept the offer of a PICC line the day it took five tries to get a working IV started. Today, no tries at all because there was a line sticking out of my arm. No need to make new holes.
Alas, there are entities in Kaiser that aren’t allowed to hook up to the PICC. So over Thanksgiving Weekend, I’ll probably have to take myself to a clinic lab, and they’ll have to make a fresh hole in me. Hopefully, after the veins have had a rest, it’ll be easier for them. (Actually, they haven’t had much trouble with a blood draw.)
The PICC (Peripherally Inserted Central Catheter) line is a catheter that’s installed into a vein, and then threaded up to the superior vena cava. This spot is chosen because it’s nice and wide, and when strong drugs are injected, there’s time for some dilution to occur before they reach the wall of the vein. I’m under the impression that the current drugs, a monoclonal antibody and a bone-strengthening agent, aren’t that nasty. But they’ll be diluted anyway.
And so with this, my exploration of 21st Century medicine continues.
Here’s a study on how Ivermectin can be “repurposed” to treat cancer. I’m going to be interested to see if any of the mechanisms of action apply to myeloma. I intend to call a specialist for a second opinion on my case, and I may run this past him if he has time.
Drug repositioning is a highly studied alternative strategy to discover and develop anticancer drugs. This drug development approach identifies new indications for existing compounds. Ivermectin belongs to the group of avermectins (AVM), a series of 16-membered macrocyclic lactone compounds discovered in 1967, and FDA-approved for human use in 1987. It has been used by millions of people around the world exhibiting a wide margin of clinical safety. In this review, we summarize the in vitro and in vivo evidences demonstrating that ivermectin exerts antitumor effects in different types of cancer. Ivermectin interacts with several targets including the multidrug resistance protein (MDR), the Akt/mTOR and WNT-TCF pathways, the purinergic receptors, PAK-1 protein, certain cancer-related epigenetic deregulators such as SIN3A and SIN3B, RNA helicase, chloride channel receptors and preferentially target cancer stem-cell like population. Importantly, the in vitro and in vivo antitumor activities of ivermectin are achieved at concentrations that can be clinically reachable based on the human pharmacokinetic studies done in healthy and parasited patients. Thus, existing information on ivermectin could allow its rapid move into clinical trials for cancer patients.PubMed
There are lots of people dismissing Ivermectin as “horse medicine”, which therefore can’t be any good for humans. I’m seeing memes on Facebook that are making this point in a number of ways.
I chose this meme because I commented on it, and wound up in a comment string that at least four people found interesting.
Welcome to Uncommon Sense, I’m Randy Cassingham.
Thanks for listening or reading, and yes, it’s been awhile! So the first thing is, I’ve definitely not abandoned the Uncommon Sense podcast. I’m just fitting it in where I can. But it is true I didn’t expect a four-month pause!
….This Is True Podcast
But I did say I’m going to start right now, so let’s delve into specifics with something that’s already been announced, but as far as I could tell none of the other attendees at the conference had heard of yet, and it got several of them pretty darned excited.
That has to do with a breakthrough regarding cancer. What kind of cancer? All of them.
August 22, 2019 is the day I had a stenosed aortic valve replaced. The procedure used was a TAVI, or transcatheter aortic valve implant. Think of the implant as a stent with a pig valve in the middle of it. It’s introduced through the femoral artery and threaded up to the location of the bad valve. Once there, it’s expanded in place, crushing the calcified valve out of the way. The pig valve takes over immediately, and the hardware used to place it is withdrawn.
Sweden, arguably one of the most politically and socially liberal countries in the world, has nonetheless taken a giant step toward protecting gender dysphoric minors and their mental, emotional, and physical well-being.
The Society for Evidence Based Gender Medicine reported on Wednesday that the Astrid Lindgren’s Children’s Hospital—an arm of the one of the most renowned hospitals in Sweden, the Karolinska University Hospital—recently released a policy statement that included new guidelines for the care of youths with gender dysphoria under the age of 16.
The guidelines, which took effect April 1, are profound: They contradict many of the assertions of the transgender lobby, which encourage parents and children to accept that cross-sex hormones and puberty blockers are normal, healthy treatments for minors with gender dysphoria and should be pursued with little hesitation.
MICROBIOME NEWS: Fecal transplant turns cancer immunotherapy non-responders into responders.
Researchers at UPMC Hillman Cancer Center and the National Cancer Institute (NCI) demonstrate that changing the gut microbiome can transform patients with advanced melanoma who never responded to immunotherapy—which has a failure rate of 40% for this type of cancer—into patients who do.
I wonder what other cancers this might apply too.
Remember when science said HCQ was useless against Covid-19? Now science says it’s an effective early medical treatment that helped 67 percent of the people to whom it was prescribed. And yes, taking zinc will help stave it off.
VOLUME 134, ISSUE 1, P16-22, JANUARY 01, 2021
The currently completed retrospective studies and randomized trials have generally shown these findings: 1) when started late in the hospital course and for short durations of time, antimalarials appear to be ineffective, 2) when started earlier in the hospital course, for progressively longer durations and in outpatients, antimalarials may reduce the progression of disease, prevent hospitalization, and are associated with reduced mortality.
In a retrospective inpatient study of 2541 patients hospitalized with COVID-19, therapy associated with an adjusted reduction in mortality was HCQ alone (hazard ratio [HR] = 0.34, 95% confidence interval [CI] 0.25-0.46, P <0.001) and HCQ with azithromycin (HR = 0.29, 95% CI 0.22-0.40, P <0.001).
Dr. Uri Ben-David of the Sackler Faculty of Medicine at Tel Aviv University, who led the research, told The Media Line that scientists have known for well over a century that malignant cells have an abnormal number of chromosomes. Humans have 46 chromosomes (two sets of 23) but in cancer this number changes because, during cell division, chromosome segregation takes place that can lead to a phenomenon called aneuploidy.
Aneuploidy, the presence of an abnormal number of chromosomes in a cell, not only causes common genetic disorders but is also a hallmark of cancer cells. Not all cancers exhibit aneuploidy, but roughly 90% of solid tumors and 75% of blood cancers do, to a certain degree.
According to Ben-David, the findings open up an entirely new avenue for medical research.
“For decades, we’ve been trying to understand why [aneuploidy] happens in cancer and how it contributes to tumor formation and progression,” Ben-David said. More importantly, he said, scientists have been trying to see “if we can take advantage of this quite unique difference between cancer cells and normal cells in order to selectively kill the cancer cells.”
Scientists found that aneuploid cancer cells were highly sensitive to the perturbation of the mitotic checkpoint — a so-called cellular mechanism which ensures proper separation of chromosomes during cell division.
Source: Jerusalem Post
I’ve got aneuploidy all over the place in my cancer — deletions, trisomy, monosomy… apparently no translocations. I’ll be interested to see if anything comes of this.