Although Hydroxychloroquine remains an approved drug and doctors can still prescribe it off-label, the FDA’s and NIH’s opinions have significant influence. State governments and medical boards adhere to the FDA opinion, in their subsequent recommendations.
But on March 16, Dr. Didier Raoult publicized his HCQ+AZ treatment regimen. Doctors in Italy and Spain started to use it, although slowly and only in hospital settings. On March 19, President Donald Trump “touted” it, immediately making this treatment popular in the world. On March 22-23, Dr. Zelenko published his protocol, adding Zinc, and, more importantly, stressing the need to treat early, without waiting for testing or hospital admission. Early HCQ+AZ treatment ramped up in Europe between March 21 and March 28. In Italy, it became the standard of care even for mild cases.
The efficacy of HCQ + AZ, with and without Zn, given early, have been reported by thousands of physicians around the world, and confirmed by more than a dozen of peer reviewed studies.